You Bet Your Life is a classic American comedy quiz show that aired on radio and television, featuring the iconic Groucho Marx as the host, alongside his announcer and assistant, George Fenneman. Debuting on ABC Radio in 1947, the show later moved to CBS Radio and eventually transitioned to both NBC-TV and NBC Radio in 1950. The show focused more on Groucho's comedic interactions with contestants than the actual gameplay. The programme was so successful that it became the first primetime series to air reruns during summer breaks, under the title "The Best of Groucho."

The last radio episode aired in 1960, and the television show continued for another year, retitled "The Groucho Show." After the show went off the air, NBC created a syndicated version in 1961, also called "The Best of Groucho," which removed all references to the original sponsors. You Bet Your Life has been revived three times since the original series concluded, with the latest version hosted by Jay Leno premiering in first-run syndication in September 2021.