The Martin and Lewis Show was a radio comedy-variety program that aired on NBC Radio Network between April 3, 1949, and July 14, 1953. The show starred the comedic duo Dean Martin and Jerry Lewis, who were widely popular for their visual comedy. Although it began with negative reviews, the show went on to gain a large following and sponsorship from companies like Chesterfield cigarettes and Anacin.

Dean Martin was the singer, and Jerry Lewis, the comedian, entertained listeners with their unique blend of slapstick humor and music. The program also featured appearances by guest stars like Dinah Shore, Jane Russell, and Ann Sheridan. The show was written by comedy writers Norman Lear and Ed Simmons and had a format consisting of an opening song, verbal slapstick, a guest spot, and a closing number performed by Martin.

The Martin and Lewis Show marked the beginning of the duo's successful career and eventually expanded into television. Their chemistry and energy made them a beloved pairing on both radio and TV, laying the groundwork for their continued impact on comedy and entertainment.