Perry Mason is a radio crime serial based on Erle Stanley Gardner's novels that aired on CBS Radio from 1943 to 1955. The show combined mystery and soap opera, focusing more on action than courtroom drama, with attorney Perry Mason sometimes engaging in shootouts with criminals. The series eventually transitioned to television as The Edge of Night, which ran for 30 additional years.

Over its radio run, several actors portrayed Perry Mason, starting with Bartlett Robinson and followed by Santos Ortega, Donald Briggs, and John Larkin, who played the character after 1947. Other significant cast members included Matt Crowley and Charles Webster as Paul Drake, Gertrude Warner, Jan Miner, and Joan Alexander as Della Street, and Mandel Kramer and Frank Dane as Lieutenant Tragg.

The radio version of Perry Mason was notably different from the Raymond Burr television adaptation, with the radio character being more action-oriented and less focused on courtroom procedures.