Nero Wolfe is a 1982 Canadian radio drama series adapted from the popular mystery series by Rex Stout. The show, which aired on the Canadian Broadcasting Corporation, features 13 hour-long episodes starring Mavor Moore as the brilliant, eccentric detective Nero Wolfe, and Don Francks as his assistant, Archie Goodwin. The series, written, produced, and directed by Ron Hartmann, is lauded for its high production values and accurate portrayal of Stout's original stories.

Set primarily in New York City, the show follows the cases of Wolfe, who prefers to solve crimes from the comfort of his luxurious brownstone. He leaves the legwork to his sharp-witted, dapper assistant, Archie Goodwin, the narrator of the series. Wolfe is known for his love of reading, orchids, and gourmet meals prepared by his personal chef, Fritz Brenner.

Nero Wolfe's radio series adaptation retains the charm and intrigue of the original stories, which garnered Rex Stout a nomination for Best Mystery Writer of the Century at Bouchercon 2000.