Mister Moto aired between May and October 1951 on the NBC Radio Network. The character Mr. Moto, a fictional Japanese secret agent, was created by the American author John P. Marquand and initially gained fame through novels and films. Belonging to the "oriental-sleuth" category, Mr. Moto shares similarities with the Chinese detective Charlie Chan. After World War II, the show featured Mr. Moto as an American agent fighting against Communist expansion.

In the nine-film series from the late 1930s, Peter Lorre played the lead, Mr. Moto. However, in the 23 radio episodes from 1951, James Monks portrayed the character. The radio adaptation focused on both Mr. Moto's fight against Communism and solving more conventional mysteries like murder and blackmail.