Mother's Best Flour was a 15-minute radio show on WSM which aired every morning from late 1950 to late 1951 featuring legendary country musician Hank Williams. Hank, the Drifting Cowboys, and announcer Louie Buck entertained Nashville's rural and mostly female audience with live music and cheerful banter while promoting Mother's Best Flour products. Williams, known for his somber tones in biographies, instead showcased a more jovial and happy-go-lucky side on this show.

The performances on Mother's Best Flour captured some of the finest work of Hank Williams during the peak of his career. The show typically included a country song, an instrumental, and a gospel song, with Hank often performing childhood favorites alongside his hits. The show also offered a glimpse into Hank's personality, revealing his appreciation for the gospel side and revealing his more cheerful side, contrary to his often-portrayed lonesome and forlorn personality.