Michael Shayne was a popular American old-time radio detective series that aired from 1944 to 1953, featuring the titular red-headed Irish detective created by author Brett Halliday. There were three versions of the show - Michael Shayne, Private Detective; The New Adventures of Michael Shayne; and The Adventures of Michael Shayne.

Wally Maher starred as Shayne in the first radio version, which began airing on the Don Lee Network in October 1944, and later moved to the nationwide Mutual network in October 1946. The second version featured Jeff Chandler in the title role and was set in New Orleans, with Don W. Sharpe as the producer. The third version aired on ABC radio from October 1952 until July 1953, with Donald Curtis, Robert Sterling, and Vinton Hayworth all taking turns in the title role.

Each version of the show focused on the hard-boiled detective Michael Shayne, who, after losing his wife, became a loner, prowling the darker streets of the post-WWII era. The character gained popularity with war veterans, and the series tackled adult themes, such as drugs and middle-class adultery.

Although Halliday did not write the radio show scripts, his Michael Shayne novels kept the public engaged and eager for more. A TV adaptation starring Richard Denning was also produced in the early 1960s.