Mark Trail was an American radio series adapted from the popular comic strip of the same name by Ed Dodd. The show featured two separate series, with the first airing from January 30, 1950 to June 8, 1951 on Mutual Broadcasting System, and the second from September 18, 1950 to June 27, 1952 on ABC Radio. Aimed at a young audience, these adventure stories starred Matt Crowley and Staats Cotsworth as Mark Trail in their respective series.

Mark Trail, a forest ranger, captivated listeners with thrilling adventures while also educating them about nature and wildlife. The radio series followed the action-packed direction of radio shows like Sergeant Preston of the Yukon. Directors Drex Hines and Frank Maxwell, along with writers and musicians, all contributed to the show's production. Notable actors who participated in the show included Ben Cooper, Joyce Gordon, and John Larkin.

The Minneapolis-St. Paul public radio station KFAI also broadcasted the Mark Trail Radio Theatre from 1991 to 2002, providing a new generation with a taste of Mark Trail's wilderness adventures.