"Challenge of the Yukon," also known as "Sergeant Preston of the Yukon," was a long-running radio adventure series created by George W. Trendle, the station owner of Detroit's WXYZ. A Northern genre story, the series began airing on February 3, 1938. The show followed Sergeant William Preston of the Northwest Mounted Police and his loyal Alaskan husky, Yukon King, as they fought evildoers in the Northern wilderness during the 1890s Gold Rush. The action-packed stories featured the duo helping injured trappers, catching smugglers, and saving people from wild animals.

The show experienced various name changes, first known as "Challenge of the Yukon," then "Sergeant Preston of the Yukon" in the 1950s. Many actors played the role of Sgt. Preston over the years, with Paul Sutton being the most prominent. The talented animal sound effects artists, Dewey Cole and later Ted Johnstone, provided Yukon King's barks and howls.

Aired on numerous networks and re-formatted as it evolved, "Challenge of the Yukon" entertained audiences with engaging storylines, lively music, and strong heroes both human and canine.